Ollie Smith and Blair Kinghorn will start in place of Stuart Hogg and Finn Russell for Scotland’s final Six Nations home match against Italy.
Full-back Hogg and fly-half Russell were ruled out after sustaining injuries in Sunday’s defeat by Ireland.
Richie Gray also drops out after being withdrawn early at Murrayfield, Sam Skinner taking over at lock.
Captain Jamie Ritchie moves to openside to accommodate Hamish Watson on the blindside as Matt Fagerson is benched.
Gregor Townsend’s side won their opening two matches in the championship before defeats by France and the Irish.
Scotland: Smith, Steyn, H Jones, Tuipulotu, Van der Merwe, Kinghorn, White; Schoeman, Turner, Z Fagerson, Skinner, J Gray, Ritchie (capt), Watson, Dempsey.
Replacements: Ashman, Sutherland, Nel, Cummings, M Fagerson, Price, Healy, Redpath.
More to follow.